LSI Seminar Series: Grant Jensen, Ph.D.
March 2, 2017 12:00pm - 1:00pmProfessor of Biology and Biophysics California Institute of Technology Investigator, HHMI “Structural biology in vivo through electron cryotomography” In the last ten years electron cryotomography has made it possible to visualize large macromolecular assemblies inside intact cells in a near-native, "frozen-hydrated" state in 3-D to a few nanometers resolution. Increasingly, atomic models of individual proteins and smaller complexes obtained by X-ray crystallography, NMR spectroscopy, or other methods can be fit into cryotomograms to reveal how the various pieces work together inside cells. A few good pictures is therefore sometimes all that is really needed to distinguish between competing models. To illustrate these points, Dr. Jensen will briefly summarize the key technological advances that have made electron cryotomography possible and then present several examples of current results from his recent work in bacterial cell biology, including new images and mechanistic insights into bacterial chemoreceptor arrays, secretion systems, and the Type IV pilus. Lunch provided.
Location: Forum Hall, Palmer Commons