Total Artificial Heart provides critical lifeline to patients

September 6, 2016  //  FOUND IN: Updates & Resources,
Stan_Larkin

Stan Larkin, a patient at UMHS, lived with a Total Artificial Heart for 555 days.

It sounds like a byproduct of science fiction: a synthetic, battery-powered device designed to replace the work of the body’s most crucial organ.

But the equipment, known as the Total Artificial Heart, offers a lifeline for some of the most severe heart-failure cases.

“That’s what the evolution of technology can do,” said Jonathan Haft, M.D., a cardiac surgeon at UMHS. “You’re actually removing the heart and replacing it.”

Haft pointed to his patient Stan Larkin, a 25-year-old with a rare form of cardiomyopathy who lived for 555 days — outside of the hospital — using a Total Artificial Heart before receiving a heart transplant at UMHS in May. “He’s absolutely thriving now,” Haft said.

The internal mechanics, which replace both ventricles and four heart valves, are regulated by two tubes that connect to a portable, 13.5-pound external air pump called the Freedom driver. (Until the Freedom driver’s approval by the Food and Drug Administration two years ago, most recipients had to rely on a hulking, 418-pound driver the size of a washing machine, which kept them hospitalized full time.)

Launched in 1969 and evolving since the 1980s, the devices aren’t for everyone.

Only the left ventricle is affected in about 85 to 90 percent of patients with advanced end-stage heart failure — which qualifies them for the smaller and less-invasive pump known as a left ventricular assist device (LVAD).

For those facing biventricular failure, however, a Total Artificial Heart is “the only real option for them,” Haft said.

Here are some fast facts that you may not know about this incredible piece of medical techology, in Dr. Haft’s own words:

They require surgery: The operation is not too dissimilar to a heart transplant; somewhere in the neighborhood of four to five hours. It can be complicated or challenged by prior operations and if someone has been in the hospital for a long period of time, the recovery could take months.

They are large: It’s noticeably bigger than a normal human heart. Patients have to undergo a CT scan to determine if there’s enough room in the chest cavity. For normal-sized people with chronic heart failure, usually it fits.

They allow mobility: The Freedom driver has a battery, so patients can be relatively untethered for a period of about two to three hours. Patients can use backup batteries if they have to leave the house for longer amounts of time. They can also plug into an outlet whenever needed.

They can be unwieldy: The external controller is large and heavy and can be a burden for people to have to carry all the time. It’s also very, very noisy. Another limitation is the two large hoses that exit the body can be cumbersome and potentially painful.

They carry risks: The No. 1 challenge is infection (via) a piercing of the skin (for the hoses) where germs can get in. With a huge amount of interface between blood and foreign surfaces, there are hazards of clots forming on the inside of the body. And if a patient is taking blood thinners, they can develop bleeding complications.

They are temporary: There are challenges with long-term support, so a TAR is intended for transplant-eligible patients or those we intend to provide a transplant once they become eligible. There are no specific time limits for the device, and the durability and risk of complications over time remain unknown.

They are evolving: The 70cc pump (the volume of blood that fills the device) has size limitations. You can’t implant it into somebody who is very small or in people with normal-sized hearts. An investigational 50cc pump currently in clinical trials could increase eligibility for smaller people.

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