Patients in skilled nursing facilities often acquire and transmit multiple bacterial infections that persist despite treatment efforts, known as multi-drug resistant organisms (MDROs).
In a five-year RO1 study funded by the National Institute on Aging, researchers from the U-M Division of Geriatric and Palliative Medicine will collaborate with the Divisions of Infectious Disease and General Medicine, as well as the School of Public Health, to determine how the following factors impact the transmission of MDROs: patient disability, prolonged exposure to the institutional environment, and intensity of contact with healthcare workers.
The researchers will first ascertain the risk of infection for different patients based on personal and environmental risk factors. In collaboration with the School of Public Health’s MAC-EPID program (Molecular and Clinical Epidemiology of Infectious Diseases), the investigators will then use innovative techniques to establish a patient profile that will help determine the optimal MDRO prevention strategies for patients who are most likely to transmit these organisms.
The impact of this translational research will be to design effective and efficient programs to prevent infections in nursing home residents while maintaining their quality of life, and to limit the transmission of MDROs across facilities. Understanding the dynamics of MDRO transmission using newer molecular epidemiology tools will shift the evolving paradigm of infection control and prevention in nursing homes.
Team: Lona Mody, M.D. (P.I., U-M Geriatric & Palliative Medicine, and Ann Arbor VA GRECC) and the Infection Prevention in Aging team, Co-investigators: Lillian Min, M.D. (U-M Geriatric & Palliative Medicine, and Ann Arbor VA GRECC), Suzanne F. Bradley, M.D. (U-M Infectious Disease, and Ann Arbor VA GRECC), Betsy Foxman, Ph.D. (U-M School of Public Health), Mary A. Rogers, Ph.D. (U-M General Medicine)